منابع مشابه
TRPV3 in Drug Development
Transient receptor potential vanilloid 3 (TRPV3) is a member of the TRP (Transient Receptor Potential) super-family. It is a relatively underexplored member of the thermo-TRP sub-family (Figure 1), however, genetic mutations and use of gene knock-outs and selective pharmacological tools are helping to provide insights into its role and therapeutic potential. TRPV3 is highly expressed in skin, w...
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Decades of characterization of the transient receptor potential vanilloid subtype 1 (TRPV1) has led to the realization of its central role in thermosensation and pain perception. A large number of pharmaceutical companies have had interest in developing TPRV1 antagonists for the treatment of pain. The subsequent discovery of multiple other members of this TRPV family has not gone unnoticed. TRP...
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TRPV3 is a thermosensitive ion channel primarily expressed in epithelial tissues of the skin, nose and tongue. The channel has been implicated in environmental thermosensation, hyperalgesia in inflamed tissues, skin sensitization and hair growth. While TRP channel research has vastly increased our understanding of the physiological mechanisms of nociception and thermosensation, the molecular me...
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2016
ISSN: 1424-8247
DOI: 10.3390/ph9030055